Recently I posted a question (here) regarding adding flavor to vodka. In my usual exuberance and non-scientific approach to matters I thought 'I know, to cut a few calories I will add Splenda'. OK, the taste was OK, the orange and lemon peel that I steeped in the vodka gave the drink a nice, if not bitter taste. I added splenda - and then experimented on myself (can't find anyone stupid enough to join me in these ventures!). I drank the 'vodka' in the same manner (volume) as I would a standard vodka or gin. Now, first morning after, the raging headache should have been sufficient - but looking for a more conclusive scientific result I tried the 'experiment' for a couple more nights, with the same results each following morning. So, my question is: Does adding an artificial sweetener to alcohol increase the chance of a hangover?
Certain people can have very individualistic headache triggers. For me it is second hand smoke. There are quite a few references on the internet tying Splenda to migraines so perhaps it so for you, at least in combination with alcohol. In any case, I'd pitch your experiment. Vodka typically has 65 calories per ounce. Sugar is about 111. However, you probably don't add that many ounces of sugar to your bottle of vodka so most of the calories will come from the ethanol. Some people substitute agave nectar which supposedly has a lower glycemic index than granulated sugar and may be healthier.